Karen H. Martin, Ph.D.
Degree Awarded: Ph.D. in Cell Biology, Duke University Medical Center (1997)
Current Title: Assistant Research Professor,
Scientific and Technical Director, Microscopic Imaging Facility
Campus Office: Room 4015 HSN
Phone: 304-293-6965
Fax: 304-293-8159
Email: kmartin@hsc.wvu.edu
Research/Education Interests:
Adhesion-mediated signaling in cell migration
Spreading rat embryo fibroblast showing cortactin (blue), pY397 FAK (red) and GFP-FRNK (green)
Publications and Grants:
K.H. Martin*, E.D. Jeffery*, P.R. Grigera*, J. Shabanowitz, D. Hunt and J.T. Parsons. 2006. Cortactin phosphorylation sites mapped by mass spectrometry. J. Cell Science 119:2851-2853.
P.R. Grigera*, E.D. Jeffery*, K.H. Martin, J. Shabanowitz, D. Hunt and J.T. Parsons. 2005. FAK phosphorylation sites mapped by mass spectrometry. J. Cell Science 118:4931-4935.
R.W. Tilghman, J.K. Slack-Davis, N. Sergina, K.H. Martin, M. Iwanicki, E.D. Hershey, H.E. Beggs, L.F. Reichardt and J.T. Parsons. 2005. Focal Adhesion Kinase is required for the spatial organization of the leading edge in migrating cells. J. Cell Science 118:2613-23.
J.T. Parsons, J.K.Slack and K.H. Martin. 2003. Integrin signaling: cell migration, proliferation and survival. Handbook of Cell Signaling. R. Bradshaw and E. Dennis, eds. Academic Press, California.
K.H. Martin, J.K. Slack, S.A. Boerner, C.C. Martin and J.T. Parsons. 2002. Integrin connections map-to infinity and beyond. Science. 296:1652-3.
S.A. Boerner, P.R. Grigera, H. Hayasaka, A.V. Karginov, A.W. Kinley, Y. Liu, K.H. Martin, P.Y. Sayess, N.V. Sergina, J.K. Slack and J. T. Parsons. 2002. Integrin Signaling Pathway. Science's STKE http://stke.sciencemag.org/cgi/cm/CMP_ 6880.
Y. Liu, J.C. Loijens, K.H. Martin and J.T. Parsons. 2002. The association of ASAP1, an ARF-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol. Biol. Cell. 13:2147-56.
K.H. Martin, S.A. Boerner and J.T. Parsons. 2002. Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor switch. Cell Motility and the Cytoskeleton. 51:76-88.
J.T. Parsons, K.H. Martin, J.K. Slack, J.M. Taylor and S.A. Weed. 2000. Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene. 19:5606-13.
J.C. Strum, K.H. Martin, J.E. Turner, R.M. Bell and K.I. Swenson. 1996. Oocyte activation and passage through the meiotic cell cycle in Xenopus laevis. Cellular and Molecular Regulation of Testicular Cells. C Desjardins, ed. Springer Verlag, New York.
J.E. Turner, C.G. Minkoff, K.H. Martin, R. Misra and K.I. Swenson. 1995. Oocyte activation and passage through the metaphase/anaphase transition of the meiotic cell cycle is blocked in clams by inhibitors of HMG-CoA reductase activity. J Cell Biol. 128:1145-62.
A.J. Udvadia, K.T. Rogers, P.D. Higgins, Y. Murata, K.H. Martin, P.A. Humphrey and J.M. Horowitz. 1993. Sp-1 binds promoter elements regulated by the RB protein and Sp-1- mediated transcription is stimulated by RB coexpression. Proc Natl Acad Sci U S A. 90:3265-9.
* Denotes equal authorship