Frank D. Reilly, Ph.D.
University of Cincinnati, 1975
Room 4010C HSN
The medical and dental gross anatomy and embryology curricula are focuses of effort at the WVU School of Medicine. In addition to teaching, there is active participation in creation, utilization, and evaluation of computer-assisted instruction in collaboration with the Educational Initiatives Group in the Department of Neurobiology and Anatomy (Figure 1).
Figure 1. Screenshot of simulated interactive patient presenting with oculomotor nerve deficit.
My collaborators and I are studying the effects of mechanical methods of closure and rapid stretching on vascular growth (angiogenesis) and healing in healthy and diabetic skin. Research targets insulin-1 gene, because insulin and insulin growth factor receptors and angiogenic intermediates are down regulated in diabetes. Non-invasive blood flow monitoring and contemporary cellular and molecular methods (DDRT-PCR, Northern and Western blotting, in situ hybridization, and immuno-histochemical staining methods) form the bases for research using animal models (Figure 2) and isolated dermal endothelial cell cultures.
Figure 2. PCNA immunostaining. Arrows indicate the nuclei of mitogenic PCNA-labeled vascular cells. Top panel: control skin. Lower panel: experimental undermined plus stretched skin.
Grants and Publications:
College of Engineering and Mineral Resources, West Virginia University, Ischemia as Related to the Timing and Cycling of Intraoperative Skin Expansion, 2001-present (active). F. Reilly, Prin. Investigator; E. Cilento, Co-Prin. Investigator.
Selected Teaching Publications:
Reilly, F., J. Altemus, J. Drake, M. Kamsala, T. Caranasos, E. Allen, D. Hunter, R. Dey, P. Klinkhachorn, B. Kraszpulska, and R. Pope. Electronic lab study guide for human structure. FASEB J., 19(4): A1353(772.1), 2005.
Reilly, F., and E. Allen. Interactive peripheral nervous system courseware evaluation. FASEB J., 20(4): A434(296.8), 2006.
Reilly, F., Bruce Palmer, Penprapa Klinkhachorn, and Holly Ressetar. Learning videos simulating neuromuscular limb deficits. FASEB J., 21(5): A212(476.1), 2007.
Klinkhachorn, P., V. Stilger, B. Palmer, F. Reilly, and Tanya Klinkhachorn1. Orthopedic ‘special’ tests for evaluating the musculoskeletal system through video learning. FASEB J., 21(5): A216(478.1), 2007.
Allen, E., R. Walls, and F. Reilly. Effects of Web-based interactive instructional techniques in a peripheral nervous system component for human anatomy. Medical Teacher 30(1): 40-47, 2008.
Reilly, F., E. Allen, and R. Walls. Interactive computer-based exercises enhance preclinical medical education. FASEB J., 23:463.6, 2009.
Selected Research Publications:
Zhu, Y., J. Luo, J. Barker, J. Hochberg, E. Cilento, and F. Reilly. Identification of genes induced by rapid intraoperative tissue expansion in mouse skin. Arch. Dermatol. Res. 293(11): 561-569, 2002.
Zhu, X., D. Hall, G. Ridenour, S. Boo, T. Jennings, J. Hochberg, E. Cilento, and F. Reilly. A mouse model for studying rapid intraoperative methods of skin closure and wound healing. Med. Sci. Monitor 9(3): 109-115, 2003.
Shrader, C., J. Luo, E. Cilento, and F. Reilly. Insulin 1 – a stretch-responsive gene-specific protein in the skin. FASEB J., 18(4): A260(197.31), 2004.
Shrader, C., J. Luo, H. Ressetar, E. Cilento, and F. Reilly. Acute stretch triggers mitogenesis in healing mouse skin. FASEB J., 19(4): A1270(693.5), 2005.
Shrader, C., M. Prescott, J. Luo, E. Cilento, and F. Reilly. Acute stretch enhances expression of Akt and VEGF in healing mouse skin. FASEB J., 20(4): A709(461.2), 2006.
Reilly, F., Shrader, C., H. Ressetar, J. Luo, and E. Cilento. Stretch responsive tissue insulin induced angiogenesis in wounded healing mouse skin. Microcirculation, 14: 449, 2007.
Reilly, F., Shrader, C., H. Ressetar, J. Luo, and E. Cilento. Acute stretch promotes vascular growth in wounded healing mouse skin. In: International Proceedings, The 8th World Congress for Microcirculation, (Julian H. Lombard, ed.), pp. 147-151, Monduzzi Editore, Bologna, Italy, 2007.
Shrader, C., H. Ressetar, J. Luo, E. Cilento, and F. Reilly. Acute stretch promotes endothelial cell proliferation in wounded healing mouse skin. Arch. Dermatol. Res., 300(9): 495-504, 2008. http://www.springerlink.com/content/f088733670g16537/
Shrader, C.D., K.M. Bailey, G.W. Konat, E.V. Cilento, and F.D. Reilly. Insulin-induced proliferation and enhanced viability of human umbilical vein endothelial cells. Arch. Dermatol. Res., 301(2): 159-166, 2009. http://www.springerlink.com/content/w521416773502356
Center for Interdisciplinary Research in Cardiovascular Sciences:
Peripheral Nervous System Website:
Testing cranial and spinal nerve functional integrity and deficits:
Extraocular skeletal muscle-induced eye movements:
Introductory head & neck radiology for preclinical learners:
Sectional and Radiological Anatomy of the Thorax:
Neuromuscular limb deficit videos: