Neuroscience Seminar Series
Co-sponsored by the Neurobiology and Anatomy Dept. and the WVU Center for Neuroscience this series presents current topics and research from local and invited speakers working in the neurosciences field.
All seminars are held Wednesdays at 4 pm, in room 2094 HSC-N
8/31/2011 Margaret Gnegy
Department of Pharmacology
University of Michigan, Ann Arbor
Protein Kinase Cb:Traffic Director for Dopamine Autoreceptor and Dopamine Transporter Activities
Dr. Gnegy’s research suggests that inhibition of protein kinase Cb could reduce extracellular dopamine in response to amphetamine
and thus have a therapeutic potential for high-dopamine release pathologies, such as drug abuse and schizophrenia.
Hosts: Rolf Hansen and the Neuroscience Program graduate students
9/28/2011 Theodore Wensel
Department of Biochemistry and Molecular Biology
Baylor College of Medicine
Exploring Structures in Sensory Neurons with Cryo-Electron Microscopy
Dr. Wensel will show how cryo-electron microscopy can be applied to the study of molecular structures, including phototransduction
complexes that mediate vertebrate vision, TRP channels that mediate multi-modal sensory signaling, and sub-cellular structures within
retinal rod cells of wildtype and genetically perturbed mice.
Host: Vishy Ramamurthy
10/5/201 Elizabeth Jonas
Departments of Medicine and Neurobiology
Life, Death and Synaptic Metabolism
Dr. Jonas will discuss how synaptic plasticity is regulated by mitochondrial ion channel activity, particularly an inner membrane leak
conductance that changes the efficiency of ATP production acutely after synaptic stimulation.
Host: George Spirou
10/12/2011 Xiao-Ming Xu
Stark Neurosciences Research Institute
Indiana University, Indianapolis
Neuroprotective and Regenerative Strategies for Repair after Spinal Cord Injury
Dr. Xu is developing novel repair strategies to improve anatomical reorganization and functional recovery in experimental models of spinal cord injuries.
Host: Aric Agmon
10/19/2011 Roger Colbran
Dept. of Molecular Physiology and Biophysics
CamKII Synaptic Signaling Mechanisms
CaMKII-associated proteins appear to play a role in targeting CaMKII to dendritic spines by activity dependent mechanisms. Dr. Colbran will
discuss the molecular basis of these interactions and their effects on glutamate receptors and regulation of synaptic transmission.
Hosts: Vishy Ramamurthy and Miranda Reed
11/2/2011 Randy Blakely
Depts. of Pharmacology and Psychiatry
Director, Conte Center for Basic Neuroscience Research
Serotonin Transporters: Single Molecule Analysis of Regulatory Pathways Connected to Autism
The serotonin transporter (SERT) is responsible for clearance of serotonin at brain and peripheral synapses, and is a major target of antidepressants
and psychostimulants such as cocaine and MDMA (Ecstasy). Dr. Blakely will describe recent efforts in his lab to explore SERT regulatory pathways,
from single molecule studies of SERT trafficking and activation to analysis of transgenic mice.
Hosts: Michael Seminerio and Lindsay Lueptow
11/30/2011 Robert Dantzer
Depts. of Psychoneuroimmunology and Pathology
Univ. of Illinois, Urbana
Why Do We Feel Sick and Behave in a Sick Way When We Are Ill? - A Neuroimmune Perspective
When we are ill with an infectious disease, we feel sick because immune mediators act on the brain via immune-to-brain communication pathways.
In his talk, Dr. Dantzer will discuss the development of sickness and its possible transition into a depressive disorder.
Host: Gregory Konat
12/7/2011 Franck Polleux
Scripps Research Institute
La Jolla, CA
Molecular Mechanisms Underlying Axon Formation and Development in Vivo
A striking feature of neuronal development is the formation of a single axon that ultimately forms presynaptic contact on target neurons. Dr. Polleux’s
lab is interested in the molecular and cellular mechanisms underlying axon formation, and Dr. Polleux will discuss the central function of the kinase
LKB1 (STK11) in axon formation and development.
Host: Eric Tucker