Works In Progress

Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Greer RO, Said SM, Schroyer KR, Chen L,Varella-Garcia M, and Weed SA. Oral Oncology, (in press).

PI-3-Kinase activation is required for PMA directed activation of cSrc by AFAP-110.  Walker VG, Gatesman Ammer AS, Cao Z, Jiang, B-H, Weed, SA, Zot, H, and Flynn DC.  AJP-Cell Physiology (submitted).

Shahab S, Kelley LC, and Weed SA.  Actin cytoskeletal mediators of invasion and metastasis amplified and overexpressed in head and neck squamous cell carcinoma.  Head and Neck (submitted).

Weed SA.  Cortactin. In: Encyclopedia of Cancer, 2nd Edition (M. Schwab, editor).  Springer-Verlag, Heidelberg, Germany. (submitted)

Recent Publications

Cortactin overexpression regulates Arp2/3 complex activity, motility and invasion in carcinomas with chromosome 11q13 amplification. Rothschild BL, Shim AH, Gatesman-Ammer AS, Irby KB, Head JA, Chen L, Varella-Garcia M, Sacks PG, Frederick B, Raben D, and Weed SA. Canc Res. 2006 Aug 15; 66(16): 8017-25.

Protein kinase C-alpha activates c-Src and iinduces podosome formation via AFAP-110. Gatesman A, Walker VG, Baisden JM, Weed SA, and Flynn DC. Mol Cell Biol. 2004 Sep;24(17):7578-97.

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells. J Cell Biol. Bougneres L, Girardin SE, Weed SA, Karginov AV, Olivo-Marin JC, Parsons JT, Sansonetti PJ, and Van Nhieu GT. 2004 Jul 19;166(2):225-35.

Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. Fan L, Di Ciano-Oliveira C, Weed SA, Craig AW, Greer PA, Rotstein OD, and Kapus A. Biochem J. 2004 Jun 1;380(Pt 2):581-91.

Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. Helwani FM, Kovacs EM, Paterson AD, Verma S, Ali RG, Fanning AS, Weed SA, and Yap AS. J Cell Biol. 2004 Mar 15;164(6):899-910.

Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells. McWilliams RR, Gidey E, Fouassier L, Weed SA, and Doctor RB. Biochem J. 2004 May 15;380(Pt 1):181-91.

Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. Abell AN, DeCathelineau AM, Weed SA, Ambruso DR, Riches DW, and Johnson GL. J Cell Sci. 2004 Jan 15;117(Pt 2):243-55.

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell. Head JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, and Weed SA. 2003 Aug;14(8):3216-29. Epub 2003 Apr 17.

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, Ware M, Jones PL, Weed SA, DeBiasi RL, Oka Y, Tyler KL, and Johnson GL. EMBO J. 2003 Jul 1;22(13):3346-55.

Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Kinley AW, Weed SA, Weaver AM, Karginov AV, Bissonette E, Cooper JA, and Parsons JT. Curr Biol. 2003 Mar 4;13(5):384-93.

Dynamin2 and cortactin regulate actin assembly and filament organization. Schafer DA, Weed SA, Binns D, Karginov AV, Parsons JT, and Cooper JA. Curr Biol. 2002 Oct 29;12(21):1852-7.

Cortactin: coupling membrane dynamics to cortical actin assembly. Weed SA and Parsons JT. Oncogene. 2001 Oct 1;20(44):6418-34. Review.

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Weaver AM, Karginov AV, Kinley AW, Weed SA, Li Y, Parsons JT, and Cooper JA. Curr Biol. 2001 Mar 6;11(5):370-4.

Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Parsons JT, Martin KH, Slack JK, Taylor JM, and Weed SA. Oncogene. 2000 Nov 20;19(49):5606-13. Review.

Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, and Parsons JT. J Cell Biol. 2000 Oct 2;151(1):29-40.

Regulation of c-SRC activity and function by the adapter protein CAS. Burnham MR, Bruce-Staskal PJ, Harte MT, Weidow CL, Ma A, Weed SA, and Bouton AH. Mol Cell Biol. 2000 Aug;20(16):5865-78.

Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Du Y, Weed SA, Xiong WC, Marshall TD, and Parsons JT. Mol Cell Biol. 1998 Oct;18(10):5838-51.

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. Weed SA, Du Y, and Parsons JT. J Cell Sci. 1998 Aug;111 ( Pt 16):2433-43.